FACTORS AFFECTING BIODEGRADATION OF THE POLYMERS

Following are the factor affecting the bio degradation of polymer 

 -Chemical structure
 -Chemical composition
 -Distribution of repeat units in multimers
 -Presence of ionic groups
 -Presence of chain defects or unexpected units
 -Configuration structure
 -Molecular weight
 -Molecular weight distribution
 -Morphology (amorphous/semi crystalline, microstructure, residual stresses)
-Presence of low molecular weight compound
-Processing condition
-Annealing
-Sterilization process
-Storage history
-Shape
-Implantation site
-Presence of absorbed or adsorbed compounds (water, lipid, ions, etc.)
-Physicochemical factors (pH, ion exchange, ionic strength)
-Physical factors (change in shape and size, variations of diffusion  coefficients, mechanical stresses, stress and solvent induced cracking)
-Hydrolytic mechanism

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