Following
are the factor affecting the bio degradation of polymer
-Chemical
structure
-Chemical
composition
-Distribution
of repeat units in multimers
-Presence
of ionic groups
-Presence
of chain defects or unexpected units
-Configuration
structure
-Molecular
weight
-Molecular
weight distribution
-Morphology
(amorphous/semi crystalline, microstructure, residual stresses)
-Presence
of low molecular weight compound
-Processing
condition
-Annealing
-Sterilization
process
-Storage
history
-Shape
-Implantation
site
-Presence
of absorbed or adsorbed compounds (water, lipid, ions, etc.)
-Physicochemical
factors (pH, ion exchange, ionic strength)
-Physical
factors (change in shape and size, variations of diffusion coefficients,
mechanical stresses, stress and solvent induced cracking)
-Hydrolytic
mechanism
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