- As the movement of drug
inside body is complex process, it is necessary to develop a generalize
approach to describe, analyse & interpret the data obtained during in vivo
drug disposition. For this, various P’ Kinetic models are used.
- P’Kinetic models provide
concise means of expressing mathematically or quantitatively the time course of
drug throughout the body & compute meaningful pharmacokinetic parameters.
- Selection of model
depends upon site & tissue being sampled , frequency of sampling
collection etc.
Uses of Pharmacokinetic
models:
-Characterizing
the behaviour of drugs in patients.
-Predicting
the conc. of the drug in various body fluids with any dosage regimen.
-Predicting
the multiple-dose conc. curves from single dose experiments.
- Calculating the optimum dosage regimen for individual patients.
- Evaluating the risk of
toxicity with certain dosage regimens.
- Correlating
the risk of toxicity with certain dosage regimens.
-Evaluating the bioequivalence /
bioinequivalence between different formulations of same drug.
-Estimating the possible drug
& / metabolite(s) accumulation in the body.
-Determining the influence of
altered physiology / disease state on drug ADME.
-Explaining drug interactions.
- There
are three approaches to study the p’kinetics of drugs
(A) compartment modeling
(B) non compartment analysis
(C ) physiological modeling
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