Fast-disintegrating sublingual Tablets

Definition :

-Fast-disintegrating sublingual tablets that disintegrate or dissolve rapidly in the patient’s mouth are convenient for young children, the elderly and patients with swallowing difficulties, and in situations where potable liquids are not available.

-Only the small volume of saliva is usually sufficient to result in tablet disintegration in the oral cavity. 

-The medication can then be absorbed partially or entirely into the systemic circulation from blood vessels in the sublingual mucosa. 

-The sublingual route usually produces a faster onset of action than orally ingested tablets and the portion absorbed through the sublingual blood vessels bypasses the hepatic first-pass metabolic processes. 

How to prepared

-To formulate rapidly-disintegrating or dissolving tablets. 

-Direct compression, one of these techniques, requires the incorporation of a superdisintegrant into the formulation, or the use of highly water-soluble excipients to achieve fast tablet disintegration.

-Direct compression does not require the use of water or heat during the formulation procedure and is the ideal method for moisture- and heat-labile medications. However, the direct compression method is very sensitive to changes in the type and proportion of excipients and in the compression forces, when used to achieve tablets of suitable hardness without compromising the rapid disintegration characteristics.

-Extremely fast tablet disintegration would be required to enhance the release of drug from tablets for rapid absorption by the sublingual mucosa blood vessels.

Evaluation

Surface pH of the tablet

Tablet weight variation

Content uniformity

Hardness

Thickness

Diameter

Disintegration time

Wetting time and

Friability