Contamination control in pharmaceutical industry

There are different ways to prevent or reduce the effect of contamination.

Following are the list to reduce the contamination 

-Personnel procedures

-Adequate premises

-Use of closed production systems

-Adequate, validated cleaning procedures

-Appropriate levels of protection of the product.

-Correct air pressure cascade

Personnel procedures: 

Clean clothing, and for clean rooms (C, B, A) non-linting clothing, to be washed in special laundries; Personal hygiene on entering a pharmaceutical area.

Adequate premises:
The minimization of the possibility of accumulation of dust; Premises with good ventilation and dedusting system.

Closed production systems: 

Closed systems, in which product is transferred from one piece of equipment to another one, without being exposed to the atmosphere.

Validated cleaning procedures: 

Manual cleaning procedures may not be reproducible. Validated cleaning procedure shall be available to clean the equipment for change over the product. So cross contamination is not possible.

Level of Protection concept: 

Good hygiene, or Level of Protection concept, specifying requirements for environmental conditions; entry procedures for personnel and material is fundamental for keeping cross-contamination under control.

Correct air pressure cascade:

Maintaining the correct air pressure differential between rooms helps prevent cross-contamination.The module on HVAC deals precisely with the last of these ways, namely a good air handling system