Definition of Cross
contamination as per WHO:
Contamination of starting material, intermediates product or
finished product with other starting material or product during production.
In simple language we can say the contamination of material
used in manufacturing with the finished product. It may be contamination of
starting material, raw material or intermediates with finished product.
Example: A, B and C are used in manufacturing
D (Finished product). The unwanted addition of A, B, C or any intermediate
produced by A, B or C with D is called cross contamination.
Cross contamination is
possible due to following reason:
- Improperly performed Operation
- Spillage of material during handling
- Improper housekeeping
- Poor air handling system
Cross contamination can be avoided by proper air handling
unit with efficacy, following of SOP and handling of material, skilled man power,
proper cleaning of equipment and follow the procedure of cleaning.
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