Transdermal drug delivery system is the formulation that is applied to the body surface and are designed to the delivery the active drug across the skin, into the system circulation.
Following are the advantages of the Transdermal drug delivery system:
-Avoid the risk and in convince of the intravenous therapy.
-Avoidance of the first pass hepatic metabolism (by the diagnosis the deactivation by digestive and liver enzyme ) thus increasing bioavailability and efficacy of drugs.
-No gastrointestinal degradation (pH, Enzymatic activity, drug interaction with food, and other orally administered drugs).
-Substitute for oral administration of medication when that route is unsuitable as with vomiting and diarrhoea.
-Extended therapy avoiding frequent dose administration.
- Permit the continuous drug administration and the use of drug with short biological half life.
- Control drug delivery for longer time.
- Bypasses the variation absorption and metabolism associated oral administration.
- Reduce the chance of over and under dosing through the prolonged pre-programmed delivery of the drug at the required therapeutic rate.
- Better patient compliance.
- Rapid termination possible when needed simply by removing the patch from the skin surface.
- Ability to modify the properties of the biological barrier to absorption.
- Easily rapidly identified for the unresponsive, unconscious or comatose patient.
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