Definition of Liposome:
A Liposome is a microvesicle composed of a bilayer of lipid amphipathic molecules enclosing an aqueous compartment.
-Liposome drugs products are formed when liposome is used to encapsulate a drug substance either within the lipid bilayer or in interior aqueous space of liposome.
-Liposome is microscopic sphere made from fatty materials prominently phospholipids.
-Liposome is made of the molecule with hydrophilic and hydrophilic ends that form hollow spheres which can encapsulate water-soluble ingredients in their inner water space and oil soluble ingredients in there in their phospholipids members that are made up of the one or more concentric bilayer, and range in size from 50 nanometers to several micrometers in diameter.
-Liposome can target a drug to the intended site of action in the body, thus enhancing its therapeutic efficacy (Drug targeting, site-specific delivery system).
-Liposome may into also direct a drug away from direct a drug from that body from that body site that is particularly sensitive to the toxic action of it.
-The liposome can act as depot from which the entrapped compound is slowly released over time. Such as sustained release process can be exploited to maintain therapeutic drug level in the bloodstream or at the local administration site for prolonging of time.
- Thus an increased duration of action and a decreased frequency of administration are beneficial consequences.
- Drugs incorporated in liposome, in particular, those entrapped in the aqueous interior, are protected against the action of detrimental factors present in the host.
-Liposome can interact with target cells in various way and therefore able to promote the intracellular delivery of drug molecules that in their free form would not able to enter the cellular interior due to the unfavorable physicochemical characteristic (DNA molecules).
- If the drug is an antigen liposome can act as immunological adjutant in vaccine formulation.
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