Difference between Normal phase and Reversed phase chromatography

Normal phase and reverse phase chromatography are the two types of chromatography the technique which is used for separation in the pharmaceutical industry. The difference between the normal phase and reversed-phase chromatography is the polarity of the mobile and stationary phase.

Normal Phase Chromatography	Reverse phase Chromatography
In normal phase chromatography, the stationary phase is more polar than the mobile phase (Hydrophilic stationary Phase)	Reverse phase chromatography stationary phase is  more nonpolar than the mobile phase  (Hydrophobic stationary Phase )
Silica is most common used stationary phase in Normal phase chromatography Diol, Amino, cyano bonded phase is the other stationary phase.	The stationary phase like C18 bonded silica, C8 is used.
And the mobile phase is more nonpolar	And the mobile phase more is polar
Hexane Heptane, Ethyl Acetate	Mobile phase like water, a polar organic solvent like methanol, acetonitrile
In Normal phase chromatography nonpolar compound elute first.	In reverse phase chromatography Polar compound elute first
Application: separation of vitamins	Separation of Pharmaceutical compound
Traditional technique nowadays not used so much	Most widely used chromatographic technique