-Chitosan is natural polymer obtained by the hydrolysis of Chitin.
- Chitosan are biopolymers which most widely used in drug delivery system.
-Chitosan is linear polysaccharide composed of randomly distributed linked D-glucosamine (deacetylated unit ) and N-Acetyl-D-glucosamine (Acetylated Unit).
Characteristic of chitosan:
-Chitin is highly insoluble in common solvents and has close resemblance to cellulose by having similar solubility profile and low chemical reactivity.
-Chitosan is a principal derivative of chitin and chitosan are distinguished by their solubility profile in dilute aqueous acid solutions.
-The characteristics properties of chitosan that render them suitable for pharmaceutical and biomedical applications.
Application :
-The chitosan has received considerable attention as possible pharmaceutical excipient in both conventional and novel application such as diluents in tablets, disintegrating agent, wet granulation, film coating hydrogel, wetting agent, bioadhesive, sustain release of drugs, site specific drug delivery system, vaccine delivery etc.
-Pharmacological properties like antacid and antiulcer activity, hypocholesterolemic action and wound healing properties.
-Hemostatic and spermicidal properties owing to their ability to bind strongly to mammalian cells by virtue of their polycationic character.
-Presence of reactive functional group and cationic character opens up possibilities for their application in controlled drug delivery.
-Favorable biological properties like biodegradability, biocompatibility, and nontoxicity.
-The chitosan matrix formulation floats and gradually swells in acidic medium
-The chitosan polymer is used in different field like agriculture as a natural seed treatment, plant growth enhancer, and bio-pesticide. The chitosan polymer can be used as a hemostatic agent in bandages in health care. Chitosan in tablet form is used as fat attractors or as dietary fiber
-Chitosan polymer also used in colon-specific drug delivery system.
Properties of Polymer
Application of Polymer
Method of studying Polymer Degradation
Characteristic of bioadhesive Polymer
Polyethylene Glycol: Polymer
Biodegradable Polymer
Biodegradation of Polymer
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